REPOSITIONING OF ANTIARRHYTHMICS FOR PROSTATE CANCER TREATMENT: A NOVEL STRATEGY TO REPROGRAM CANCER-ASSOCIATED FIBROBLASTS TOWARDS A TUMOR-SUPPRESSIVE PHENOTYPE

Abstract Background Cancer-associated fibroblasts (CAFs) play a significant role in fueling prostate cancer (PCa) progression by interacting with tumor cells.A previous gene expression analysis revealed that CAFs up-regulate genes coding for voltage-gated cation channels, as compared to normal prostate fibroblasts (NPFs).In this study, we explored

The outcomes of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) resistant to new drugs such as tyrosine kinase inhibitors, inotuzumab ozogamicin (InO) and blinatumomab are dismal.We treated two cases of Ph+ALL resistant to these drugs that achieved long-term survival after treatment with chimeric antigen receptor (CA

Background: Histocompatibility testing (HT) which includes donor-recipient human leukocyte antigen (HLA) matching, cross-match testing (XMT) and anti-HLA antibody searching are crucial examinations in solid organ transplantation aiming to avoid the hyperacute graft rejection and also to predict the immunological outcome of the graft.Aims: The aim o

Drought is a common disturbance in arid-land streams and rivers.The survival of aquatic species depends on access to refuge habitats where water quality remains high.Over the past century, modified flow regimes and altered watershed and instream characteristics have led to the extinction and endangerment of numerous fish species endemic to the sout

Abstract The topology of the network of load transmitting connections plays an essential role in the cascading failure dynamics of complex systems driven by Decorative Bowls the redistribution of load after local breakdown events.In particular, as the network structure is gradually tuned from regular to completely random a transition occurs from th